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Research Journal of Chemistry and Environment (RJCE)

Hepatoprotective Activity of Tradescantia spathacea, Extract against Paracetamol Induced Hepatic Damage in Rats

By, S. Shaheen Sultana, S. Tasqeeruddin, Yahya I. Asiri, N.S. Murali Krishna, S. Nishath Sultana, Journal ID: RJCE-22-07-2020-27
(This article belongs to Vol - 13, Issue - 03)

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Abstract

Tradescantia spathacea Swartz (family: Commelinaceae) was medicinally used in the Southeastern of Mexico and India, for its hepatitis, cancer and diabetes curative efficacy. No longitudinal research on protective effect has been carried out T. Spathacea is used for treating liver diseases. So, the present study focused on the Hepatoprotective Activity of Methanolic extract of Tradescantia spathacea (METS) against Paracetamol Induced Hepatic Damage in Rats. Five rat groups(n=6) were used and administered once daily by vehicle (saline), control (vehicle + PCM 1 ml / kg, p.o), 100 mg / kg silymarin (positive control), METS (250 and 500 mg / kg p.o.) for 9 days, accompanied by paracetamol (PCM) hepatotoxicity induction. Blood samples and livers were collected and analysed biochemically and microscopically. METS at a dose level of 250mg / kg p.o. and 500mg / kg p.o. significantly induced (p<0.05) hepatoprotection by decreasing serum levels of Aspartate amino transferase (AST), Alanine amino transferase (ALT), Alkaline Phosphatase (ALP), and Total Serum Bilirubin (SB) but significantly increased dose-dependent levels of glutathione (GSH). METS results were comparable with that typical medication, silymarin. Histopathological results supported METP's beneficial function against Paracetamol (PCM)-induced liver damage in rats. METS at a dose level of 250 and 500mg / kg showed significant hepatoprotective activity.

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